Phosphatidylcholine (PC) is a vital component of the cellular membranes of plant and animal cells, necessary for membrane integrity, structure, and function. PC also is a normal constituent of bile and facilitates fat emulsification, absorption, and transport. Choline, provided by PC, is a precursor for the synthesis of acetylcholine, an important neurotransmitter centrally in the brain, and necessary peripherally for muscle control and other aspects of cholinergic signalling. Choline is considered an essential nutrient and must be obtained from the diet.* Although thresholds have been established for adequate intake of choline, studies have shown that this may not be sufficient for prevention of symptoms of choline deficiency such as fatty liver or muscle damage.* The risk of choline deficiency is higher in men, postmenopausal women, vegans or vegetarians, and individuals with genetic polymorphisms related to folate or choline metabolism. Sufficient levels of PC and choline are also necessary for homocysteine metabolism, fetal development, neurocognitive health, and liver detoxification of chemicals, heavy metals, and xenobiotics.* Choline supports the body’s antioxidant status, reducing lipid peroxidation, and is also a major source of methyl groups via its metabolite trimethylglycine (TMG), which is important for Phase II hepatic detoxification.